Eye Cleanser

The safe & effective solution for cleaning red, itchy, crusty, inflamed eyes

Primocyn Eye Cleanser is the safe & effective solution to good eyelid & eyelash hygiene.

hypochlorous acid (HOCl)
Steroid-Free
Antibiotic-Free
Non-Irritating
Non-Cytotoxic
Non-Sensitizing
Requires No Special Handling

For the safe and effective removal of encrustation and debris.
Primocyn Eye Cleanser contains hypochlorous acid (HOCl) which has been proven to be safe in over five million users to date. HOCl at the concentration levels found in Primocyn Eye Cleanser can be used safely around eyes, ears, nose, and mouth.

What is hypochlorous acid (HOCl)?

HOCl is a compound that is produced naturally by the immune system, particularly neutrophils, to eradicate microorganisms.1

Benefits of HOCl
Stabilized hypochlorous acid (HOCl) helps reduce itch, inflammation and pain. It is also a powerful antimicrobial that kills skin pathogens associated with blepharitis, MGD, demodex and dry eye.

Who will HOCl help and what are the benefits?

HOCl has several specific properties that are beneficial for various skin conditions including those around eyelids and eyelashes. These include:

Potent antimicrobial
Reduction of pain and itch
Reduction of inflammation
Breaks down biofilm formed by S. aureus

Blepharitis

MGD

Demodex

Dry Eye

Not all HOCl solutions are created equal

The positive effects of HOCl on the human body, both inside and out, have been studied and Recognized by medical scientists worldwide for over 100 years.

Today, Hypochlorous acid is bottled in a stabilized form so that you have a weapon to use against The countless environmental aggressors that threaten the health of your skin.

Don’t be fooled by others who claim to have superior HOCl solutions. Primocyn’s original HOCl formulas have been continuously improved over time and have set the standard of quality, stability and efficacy.

Potent Antimicrobial

Time Kill Study: In vitro HOCl eradication of pathogens

Greater than 99% reduction in killing 23 different microorganisms, including S. aureus and S. aureus-MRSA
Time to kill 30 seconds

Learn about the in-solution time kill.

Name of Organism	Log Reduction	Log Reduction	Percent Reduction
Acinetobacter baumannii	7.0488	30 seconds	99.9999%
Bacteroides fragilis	3.3565	30 seconds	99.9560%
Candida albicans	6.4699	30 seconds	99.9999%
Corynebacterium diphtherieae	5.2778	30 seconds	99.9995%
Clostridium difficile (spores)	4.6085	30 seconds	99.9975%
Enterobacter aerogenes	6.7200	30 seconds	99.9999%
Enterococcus faecalis-VRE MDR	5.6085	30 seconds	99.9998%
Escherichia coli	6.5272	30 seconds	99.9999%
Haemophilus influenzae	5.4107	30 seconds	99.9996%
Klebsiella oxytoca	6.7810	30 seconds	99.9999%
Klebsiella pneumoniae ozaenae	6.8086	30 seconds	99.9999%
Malassezia furfur	5.3953	30 seconds	99.9996%
Micrococcus yunnanensis	5.6137	30 seconds	99.9998%
Propionibacterium acnes	5.2967	30 seconds	99.9995%
Proteus mirabilis	6.7477	30 seconds	99.9999%
Pseudomonas aeruginosa	6.5867	30 seconds	99.9999%
Serratia marcescens	6.5811	30 seconds	99.9999%
Staphylococcus aureus-MRSA	6.7032	30 seconds	99.9999%
Staphylococcus aureus	6.5008	30 seconds	99.9999%
Staphylococcus pyogenes	6.4214	30 seconds	99.9999%
Trichophyton mentagrophytes	4.6752	30 seconds	99.9979%
Trichophyton rubrum	2.5234	30 seconds	99.7004%
Vibrio vulnificus	5.1888	30 seconds	99.9994%

Reduction in Pain and Itch

Case Study #1

Open-Label Study

Study Design

Open-label, single-arm study over 7 days

Results

HOCl rapidly reduces pruritus in mild-to-moderate atopic dermatitis (AD)

50% of patients experienced a reduction by Day 1
85% of patients experienced a reduction by Day 3

Percent of patients with improvement in pruritus

Case Study #2

Randomized, Blinded, Controlled Study

Study Design

72-hour study
Treated group (n=19): HOCl BID
Untreated group (n=10): No treatment

Results

Mean pruritus VAS scores between treated and untreated group were significantly different between baseline and 72 hours post application

Anti-Inflammatory Activity

HOCl for Inhibition of Mast Cell Degranulation

Prevents allergen- and calcium-induced mast cell degranulation for up to 8 hours after a single exposure in-vitro
Reduces wound inflammation that inhibits healing
Stabilizes the mast cell membrane to inhibit the cell machinery for granule secretion, while not altering the signal transduction pathways or calcium mobilization
Inhibits degranulation stimulated by antigen or calcium ionophore

HOCI inhibition of mast cell degranulation stimulated by antigen or calcium lonophore

Breaks Down Bacterial Biofilm

Biofilm formation is recognized as a serious problem in chronic wound infections. Biofilm characteristics include

Complex structure of microorganisms that generate a protective shell, allowing bacteria to collect and proliferate
Most microorganisms that form biofilms found growing in microbial infection
Adheres to chronic wounds, makes phagocytosis difficult, and increases resistance to antibiotics
Inhibits degranulation stimulated by antigen or calcium ionophore

HOCl has antibiofilm activity and actively breaks down biofilm and kills microorganisms within the biofilm.

In vitro biofilm eradication of slime-producing S. aureus with serial dilutions of HOCI

Increases Oxygenation

Provides higher levels of oxygen at a wound site after application
Elevated blood and oxygen flow increases wound-healing nutrients

Assists Wound Healing

Wound healing involves a complex sequence of events. Fibroblasts are the primary synthetic cells in the repair process of most structural proteins used during tissue reconstruction.

At lower concentrations, the percentage of fibroblast migration exceeded that of the control at 24 hours.

Effect of HOCI on skin fibroblast cell migration in a wound healing assay

Although fibroblasts have a critical role in wound healing, their proliferation highly relates to keratinocyte proliferation and mediators secreted from keratinocytes.

Similar results were obtained for keratinocyte migration: At lower HOCl concentrations, the percentage of keratinocyte migration exceeded that of the control at 24 hours